Gold Nanoparticles in Interferometric Scattering Microscopy for High-Resolution Detection

Introduction

Interferometric Scattering Microscopy (iSCAT) is an advanced technique for detecting and analyzing nanoparticles at extremely high resolutions. Nanopartz offers specialized gold nanoparticles optimized for interferometric scattering microscopy applications, providing enhanced imaging quality and sensitivity. iSCAT enables researchers to observe and track particles, proteins, and cellular structures with precision, making it ideal for various fields, including molecular biology, materials science, and nanotechnology.

Why Use Gold Nanoparticles in Interferometric Scattering Microscopy?

Gold nanoparticles are ideal for iSCAT due to their strong scattering properties and compatibility with biological environments. When illuminated in an iSCAT setup, gold nanoparticles scatter light effectively, creating a distinctive interference pattern that enhances image contrast and resolution. Nanopartz gold nanoparticles are tailored for this method, offering optimal size, shape, and surface functionality to ensure superior imaging performance.

Applications of Gold Nanoparticles in iSCAT

• Molecular and Cellular Imaging: iSCAT with gold nanoparticles enables single-molecule imaging, allowing scientists to study biomolecular interactions at the nanoscale.
• Virus and Pathogen Detection: Gold nanoparticles enhance sensitivity in pathogen detection by producing distinct interference patterns, making iSCAT useful for real-time diagnostics.
• Nanoparticle Tracking: iSCAT’s precise tracking capabilities are ideal for studying the behavior of gold nanoparticles in dynamic systems, like drug delivery models and cell membrane interactions.

Key Benefits of Nanopartz Gold Nanoparticles for iSCAT

• High Sensitivity: Nanopartz gold nanoparticles scatter light strongly, providing high-contrast images even at low particle concentrations.
• Customizability: With customizable sizes, shapes, and surface coatings, these nanoparticles can be tailored to fit specific research needs.
• Biocompatibility: Designed to be safe for biological applications, Nanopartz nanoparticles can be used in live-cell imaging with minimal toxicity.

For cutting-edge research requiring high sensitivity and precision, Nanopartz gold nanoparticles for interferometric scattering microscopy deliver unmatched performance and adaptability.

References:

Young & Kukura (2019) "Interferometric Scattering Microscopy" Annual review of physical chemistry (2019) doi:10.1146/annurev-physchem-050317-021247 publication type: research support, non-u.s. gov't, article, topics: physics used: Defines fundamentals of iSCAT

Taylor & Sandoghdar (2019) "Interferometric Scattering Microscopy: Seeing Single Nanoparticles and Molecules via Rayleigh Scattering" Nano letters (2019) doi:10.1021/acs.nanolett.9b01822 publication type: research support, non-u.s. gov't, article, topics: scattering, optics, medicine used: Further explains iSCAT

Arroyo et al. (2014) "Label-Free, All-Optical Detection, Imaging, and Tracking of a Single Protein" Nano letters (2014) doi:10.1021/nl500234t publication type: article, research support, non-u.s. gov't, research support, n.i.h., intramural, research support, n.i.h., extramural, topics: nanotechnology, microscopy, interference, materials science, optics, myosin subfragments, optical imaging used: Defines fundamentals of iSCAT

Taylor & Sandoghdar (2019) "Interferometric Scattering (iSCAT) Microscopy and Related Techniques" (2019) doi:10.1007/978-3-030-21722-8_2 publication type: book, topics: optics, interferometry, microscopy used: Provides additional details on iSCAT applications

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