All About Hollow Gold Nanoshells

Definition, Properties and Applications

Hollow gold nanoshells are a novel type of metal nanostructure that combine the morphological characteristics of hollow metal nanoshells and nanorods (Sanchez-Gaytan & Park, 2010). These nanoshells have gained attention due to their unique properties, such as high stability, biocompatibility, and tunable optical properties (González et al., 2023; Morgan et al., 2019; Tuersun et al., 2015). The hollow structure allows for a high payload capacity, making them suitable for drug delivery applications (Morgan et al., 2019). Additionally, they have been shown to exhibit efficient conversion of near-infrared (NIR) irradiation into heat, which is promising for photothermal cancer therapy (Wang et al., 2016). The tunable optical properties of these nanoshells, coupled with their high chemical stability and good biocompatibility, make them promising for various biomedical applications (Tuersun et al., 2015).

The properties of hollow gold nanoshells make them suitable for a wide range of applications. They have been investigated for drug delivery systems due to their high payload capacity and efficient release of cargo (Morgan et al., 2019). Furthermore, their ability to efficiently convert NIR irradiation into heat makes them promising for photothermal cancer therapy (Wang et al., 2016). The tunable optical properties of these nanoshells, coupled with their high chemical stability and good biocompatibility, make them suitable for biomedical applications such as contrast agents for optical coherence tomography, as well as for hyperthermia applications (Agrawal et al., 2005; Huang et al., 2016). The unique properties of hollow gold nanoshells also make them attractive for use in biomedical imaging and cancer therapy (Li et al., 2009).

In addition to their applications in drug delivery and cancer therapy, hollow gold nanoshells have also been studied for their potential in other biomedical applications. For example, they have been investigated for their use in photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature (Li et al., 2009). Furthermore, their tunable optical properties make them suitable for use in biomedical imaging (Tuersun et al., 2015). The unique properties of hollow gold nanoshells also make them attractive for use in biomedical imaging and cancer therapy (Li et al., 2009).

In conclusion, hollow gold nanoshells are a promising class of nanomaterials with unique properties that make them suitable for a wide range of biomedical applications. Their high stability, biocompatibility, and tunable optical properties make them attractive for drug delivery, photothermal cancer therapy, biomedical imaging, and other biomedical applications.

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References:

Agrawal, A., Huang, S., Pfefer, T., & Drezek, R. (2005). Quantitative evaluation of nanoshells as a contrast agent for optical coherence tomography.. https://doi.org/10.1117/12.632991

González, J., García-Casillas, P., & González, C. (2023). Gold nanoparticles as drug carriers: the role of silica and peg as surface coatings in optimizing drug loading. Micromachines, 14(2), 451. https://doi.org/10.3390/mi14020451

Huang, C., Chu, S., Li, C., & Lee, T. (2016). Surface modification with zwitterionic cysteine betaine for nanoshell-assisted near-infrared plasmonic hyperthermia. Colloids and Surfaces B Biointerfaces, 145, 291-300. https://doi.org/10.1016/j.colsurfb.2016.05.004

Li, M., Wang, J., Schwartz, J., Gill-Sharp, K., Stoica, G., & Wang, L. (2009). In-vivo photoacoustic microscopy of nanoshell extravasation from solid tumor vasculature. Journal of Biomedical Optics, 14(1), 010507. https://doi.org/10.1117/1.3081556

Morgan, E., Wupperfeld, D., Morales, D., & Reich, N. (2019). Shape matters: gold nanoparticle shape impacts the biological activity of sirna delivery. Bioconjugate Chemistry, 30(3), 853-860. https://doi.org/10.1021/acs.bioconjchem.9b00004

Sanchez-Gaytan, B. and Park, S. (2010). Spiky gold nanoshells. Langmuir, 26(24), 19170-19174. https://doi.org/10.1021/la1038969

Tuersun, P., Han, X., & Ren, K. (2015). Backscattering properties of gold nanoshells: quantitative analysis and optimization for biological imaging. Procedia Engineering, 102, 1511-1519. https://doi.org/10.1016/j.proeng.2015.01.285 Wang,

H., Liu, X., Li, X., Liu, W., & Jiang, L. (2016). One-pot seedless synthesis of uniform gold nanoshells and their photothermal conversion property. Chemistryselect, 1(4), 659-663. https://doi.org/10.1002/slct.201600017