Nanopartz Microgold
Nanopartz™ Microgold are rod shaped gold nanoparticles manufactured using proprietary methods that result in exact sizes, highly monodisperse sizes and shapes, long shelf lives, along with significantly improved reactivity. Microgold are 75-150 nanometers in diameter and up to 2 microns in length. Microgold are the largest known "nanoparticles" available - and the largest that can still be considered nanoparticles. These particles match the wavelength of light in the longitudinal dimension providing single particle detection under white light microscopy with simple instrumentation. They have approximately 100 times the scattering cross section as a 100 nm spherical gold nanoparticle, 100,000 to 1,000,000 times the scattering of a 1.4 nm gold nanoparticle. As with all of Nanopartz products, they are highly monodisperse. Every batch is completely characterized including size, monodispersity, aggregation, residual chemicals, and concentration. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data. Every product is in stock (99%) and is shipped same day. This product comes in two concentrations, regular OD=0.05 (0.05mg/mL), and highly concentrated OD=5 (5mg/mL) in DI water, purified of residual reactants to <0.1%. These particles are are available non-covalently capped with our own proprietary carboxylic acid, citrate, and many other adsorbed polymers. These capping agents are readily replaced with covalent and charge chemistries.
These particles are not manufactured in citrate. Citrate and the other ligands are functionalized after manufacturing allowing for a minimal, controlled amount of ligand to be used.
Want to know more? Go to All About Microgold
Product Image Left to Right, A13-500 to A13-2000
| Part # | Diameter (nm) | Length (nm) | Aspect Ratio | Peak SPR Wave (nm) | SPR OD (1cm) | Microgold /mL | Wt. conc (mg/ml) | SPR Molar Ext. (M-1cm-1) |
| A13-500 | 75 | 500 | 6.7 | 510 | 0.05 | 1.24E+09 | 0.05 | 2.43E+07 |
| A13-1000 | 100 | 1000 | 10 | 510 | 0.05 | 3.42E+08 | 0.1 | 8.78E+07 | A13-2000 | 150 | 2000 | 13.3 | 510 | 0.05 | 7.53E+07 | 0.1 | 3.98E+08 |
MW (g/mole) |
Zeta Charge (mV) |
Salt resistant? |
Concentration Sensitive? |
Easy to adsorb proteins? |
Easy to thiolate? |
Shelf Life at 4C |
|
Citrate |
192 |
-35 |
1.5mM |
Yes |
Yes |
Yes |
6 months |
Nanopartz Carboxylic Acid |
212 |
-30 |
15mM |
Less than Citrate |
Better than Citrate |
Better than Citrate |
years |
PEI |
100K |
30 |
150mM |
No |
Yes |
Yes |
6 months |
PAA |
10K |
-30 |
150mM |
No |
Yes |
Yes |
6 months |
PAH |
10K |
20 |
150mM |
No |
Yes |
Yes |
6 months |
PVP |
40K |
-10 |
0.5M |
No |
No |
Yes |
6 months |
CTAB |
364 |
35 |
0.5M |
Yes |
No |
No |
6 months |
BSA |
66K |
-15 |
0.5M |
No |
No |
No |
6 months |
Composition
These bare Microgold are shipped in DI water in 5mM CTAB.
Custom Formulation
Diameters 75 to 150nm, lengths 500 to 2000nm. Other sizes are special order. Please contact us.
Quantity
This product is available in 5mL and larger. For orders larger than 100mL, or for orders amounting over 10L per annum, please contact sales for quantity pricing.
Delivery
Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays.
Conjugations
This product comes standard with CTAB.
Shelf Life/Storage Temperature
This product is guaranteed for six months and should be stored at 4°C after opening. Care must be taken to only use sterile glassware when working with this product.
Toxicity
This product is known to be cytotoxic.
Certifications
This product is manufactured using our audited ISO 9000 quality control system. Every order comes with a Certificate of Analysis. We use NIST traceable:
UV-VIS (Agilent 8453) for extinction and concentration measurements
NIR (Cary 500) for NIR extinction and concentration measurements
DLS (Malvern Nano ZS) for zeta potential measurement
ICP-MS (Varian 820-MS) for gold mass measurements
TEM (Phillips CM-100 100KV) for sizing
Can I use these bare microgold particles in my in-vitro experiments?
The CTAB provides a positive zeta potential that is very attractive for intercellular uptake. However, the CTAB is not covalently bound and is known to be cytotoxic. We recommend our MUTAB coated microgold that you can find in our in-vitro section.
What is the SPR for this product?
There is no Surface Plasmon Resonance for this particle as the diameter and length are too large, so these are not recommended for dark field microscopy. However, they are large enough to reflect light and are very advantageous for bright field microscopy.
Why are these particle so advantageous for in-vitro applications?
They have been shown to be the perfect size for intercellular uptake.
"I just wanted to say thank you! I am very proud of this research and I could not have done it without your nanoparticles and support. Look in the future for published work by us using these nanoparticles as well. Should be happening in the next few months. Thanks again."
Kellie Waterman
Graduate Student
Worcester Polytechnic University
Shape-dependent oriented trapping and scaffolding of plasmonic nanoparticles by topological defects for self-assembly of colloidal dimers in liquid crystals
nanobursts (NBs) and nanorods (GNRs) with NSol(akyl acrylate) polymer conjugation (Figure
1a–d) were obtained from Nanopartz, Inc. ... Microgold (MG), NSol(akyl acrylate), 150, 800, 235, ...
The manufacturing method for these microparticles are based on our proprietary methods. This invention allows for the manufacturing of highly monodisperse gold microparticles. Micron sized particles are advantageous for white light microscopy applications as single particles can be seen under 40x objectives. This product replaces silver growth chemistries and its size is particularly advantageous in cellular uptake.
All of these "bare" particles are capped with ligands that are easily replaced with thiol and charge chemistries.
| Nanopartz™ Microgold | Other Technologies | |
| Monodispersity | High (<10%) | n/a |
| Size Accuracy | High (25nm) | n/a |
| Linewidths | Narrow | n/a |
| Storage lifetime | Years | n/a |
| Ability to ligand exchange | Easy | n/a |
- Largest know gold nanomaterial.
- Single particles can be seen in white light microscopy.
- Many conjugation options.
- Advantageous size for intracellular uptake.
- Perfect for microscopy labeling without silver growth.
- Applications in tribological additives.
- Large size enables use as labels in electron microscopy.
Example part number is A13-500-CIT-DIH-1-5-CS-EP where:
A13 - Product family number for Microgold
500 - Length in nanometers. Other choices are 1000, 2000
CIT - Capping ligand, in this case Citrate. Other choices are NPC, CTAB, PAA, PVP, PEI, PAH, PSS, BSA
DIH - Buffer, in this case 18MEG DI water. Other choices are PBS, MES, Sodium Borate, TRIS
1 - 0.05mg/mL concentration, other choice is 100 which is 5mg/mL
5 - Volume (mL). Other choices are 25mL.
CS - Certified Sterilized - Though the product come sterilized, this option includes testing and certification.
EP - Endotoxin Purified - The product is endotoxin purified and certified.