Nanopartz In Vivo Gold Nanoparticles

At Nanopartz, we specialize in providing cutting-edge in vivo gold nanoparticles for cancer therapeutics and cancer diagnostics research. Our nanoparticles have been used in countless publications - designed to enhance drug delivery, improve cancer imaging, and facilitate early detection of tumors, making them ideal for advancing cancer research and clinical applications.

Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to MDA-MB-435 tumors 72 hours after IV administration. (Nanopartz/MIT collaboration results)

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• Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to MDA-MB-435 tumors 72 hours after IV administration. (Nanopartz/MIT collaboration results)
• Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to soft tissue sarcoma tumors in canines 72 hours after IV administration. 10W 808nm laser was used for heating. (Nanopartz Clinical Trials)
• Image of Nanopartz GNR labeled cell subsequently labeled with the live cell dye Calcein-AM, shown in red. From Motamedi 2011 BOE (2)5. NCBI Copyright Approval.
• Ex vivo 3D photoacoustic images taken at 750nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
• Two photon image using low incident power of 1mW following intravenous injection of Nanopartz gold nanorods in Hamster Model showing blood vessels in the tissue. From Motamedi 2011 BOE (2) 5. NCBI Copyright Approved.
• White light microscopy images of control tumor and GNS and Nanopartz Ntracker GNR injected mice. (Pink: cytoplasm stained with eosin, Dark Blue: nuclei stained with hematoxylin). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
• TPIP images of Tumor model (Green: cytoplasm stained with eosin, Yellow: GNSs and Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
• TPIP images of Nanopartz gold nanorod injected mice with nuclei staning (YOYO-1 iodide). Two photon IP image with FOV of 720x490um measured at the distance of approximately 100um inside the tumor edge. (Green: nuclei, Yellow: Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
• Two Photon IP images of Nanopartz gold nanorod injected mice with blood vessel staining (CD31 immunofluorescence staining). TPIP image with FOV of 790x520um. Red: blood vessels, Yellow: Nanopartz Ntracker Gold Nanorods. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
• Two Photon IP images of liver of Nanopartz Ntracker gold nanorod injected mice. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
• In vivo imaging of single gold nanorods in mice ear blood vessels. Overlay of transmission image (light blue) and a single frame TPL image. Two single nanorods (red spots) are superimposed by a linescan (white). From Wei Nanomedicine (Lond). 2007 February 2(1) 125-132. NCBI Copyright Approval.
• B Mode and photoacoustic images of subcutaneous tumor before and 2 minutes after a 200uL bolus of Nanopartz gold nanorods. Photoacoustic contrast in enhanced by gold nanorods in vasculature. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
• Ex vivo 3D photoacoustic images taken at 750nm of the excised spleen of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse spleen. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
• Ex vivo 3D photoacoustic images taken at 750nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
• Ex vivo 3D photoacoustic images taken at 970nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
• Gold nanorod contrast enhanced Optical Coherence Tomography images of a human breast carcinoma tissue sample. The sturcutral OCT image is presented in red, and the SOCT computed GNR density is presented in green.

Nanopartz™ gold nanoparticles for in vivo include both the Ntracker™ and Ntherapy™ family of nanorods, along with customer defined oligo and antibody conjugated nanrods for in vivo applications. The Ntracker™ non reactive methyl terminated nanorods are coated in a proprietary dense layer of hydrophilic polymers that shield the gold surface and give the particles ultra-long circulation times. Ntherapy™ nanorods come with similar hydrophilic polymers, but with terminal amine and carboxyl active groups, along with a number of custom popular in vivo targeting ligands. Ntherapy™ also provides an opportunity for the customer to define their own targeting ligands utilizing Nanopartz™ nanorod and polymer technologies. In this family, Nanopartz™ has the ability to covalently conjugate to specific antibody locations, thereby for example, leaving necessary primary amines exposed for optimum activity. The combination of the highly monodisperse Nanopartz™ gold nanorods with the proprietary Nanopartz™ polymers increase circulation times 50% longer than other commercial polymers thereby significantly improving targeting.

See our original publications for companion animal photothermal therapy here:

Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.

Schuh, Elizabeth M., et al. “Safety and Efficacy of Targeted Hyperthermia Treatment Utilizing Gold Nanorod Therapy in Spontaneous Canine Neoplasia.” BMC Veterinary Research, vol. 13, 2017, p. 294.

As opposed to other commercially available nanoparticles such as quantum dots, Nanopartz™ in vivo line of nanorods are completely non-toxic. Whereas Ntracker™ takes advantage of the Enhanced Permeability and Retention effect (EPR) for passive in vivo targeting, Ntherapy™ utilizes popular ligands for active targeting. This product line comes in a diameter of 10nm with SPRs matching all of the popular Near IR CW laser wavelengths; 780, 808, 850, 980, and 1064nm. Ntherapy™ offers options for oligo and customer detailed conjugations. Every batch is radiation sterilized in PBS, and comes with instructions for in vivo mouse iv injection. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data. Every product is in stock (99%) and is shipped next day for many ligands. This product comes in two concentrations, regular 1.75mg/mL, and highly concentrated 10mg/mL.

Applications of In Vivo Gold Nanoparticles in Cancer Therapeutics, Imaging and Diagnostics:

Nanopartz in vivo gold nanoparticles are used in a variety of applications that significantly impact cancer treatment and diagnostic procedures:

Nanopartz in vivo gold nanoparticles have several significant applications in cancer therapeutics, imaging, and diagnostics due to their unique optical, thermal, and biocompatible properties. Below are the key applications:

1. Photothermal Cancer Therapy

• Mechanism: Gold nanoparticles (especially gold nanorods) absorb near-infrared light and convert it into heat, effectively destroying cancer cells through localized hyperthermia.
• Application Example: Nanopartz gold nanorods have been used in photo-thermal cancer therapy to selectively heat and destroy tumors without damaging surrounding healthy tissue.
• Research Reference: Fourkal, E., et al. "Photo-Thermal Cancer Therapy Using Gold Nanorods." World Congress on Medical Physics and Biomedical Engineering, Springer, 2009; Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.

2. Targeted Drug Delivery

• Mechanism: Functionalized gold nanoparticles can carry therapeutic agents directly to cancer cells, increasing the efficacy of treatment while minimizing side effects.
• Targeted Ligands: Nanoparticles can be conjugated with targeting ligands like antibodies, peptides, or folate, which bind to specific receptors overexpressed by cancer cells (e.g., EGFR, folate receptors).
• Application Example: Gold nanoparticles are engineered for precise delivery to tumor sites, where they release the drugs under specific stimuli like light or pH change.

3. Imaging and Diagnostics

• Optical Imaging: Gold nanoparticles, including gold nanorods and core-shell nanoparticles, enhance contrast in various imaging modalities such as Optical Coherence Tomography (OCT) and Surface-Enhanced Raman Scattering (SERS).
• Application Example: Nanopartz gold nanoparticles are used for imaging tumor progression and metastatic tracking. Fluorescently-labeled gold nanoparticles can be used in vivo for micro-CT and optical projection tomography.
• Research Reference: Kozomara, S. "Assessment of Fluorescently-Labeled Gold Nanoparticles in Mice as a Contrast Agent for Micro-Computed Tomography and Optical Projection Tomography." University of British Columbia, 2019.

4. Biodistribution and Cellular Uptake Studies

• Mechanism: Understanding how gold nanoparticles distribute in the body and their interaction with cancer cells helps improve therapeutic delivery and imaging efficiency.
• Application Example: Nanopartz gold nanoparticles are used in studies to track their distribution in tumors and organs, enabling optimization of dosage and targeting strategies.
• Research Reference: Janát-Amsbury, M. M., et al. "Geometry and Surface Characteristics of Gold Nanoparticles Influence Their Biodistribution and Uptake by Macrophages." European Journal of Pharmaceutics and Biopharmaceutics, 2011.

5. Photodynamic Therapy (PDT)

• Mechanism: In combination with photosensitizers, gold nanoparticles can be used in photodynamic therapy, where light activation leads to the generation of reactive oxygen species (ROS) that kill cancer cells.
• Application Example: Nanopartz gold nanoparticles, functionalized with photosensitizers, enhance the efficacy of photodynamic therapy for solid tumors.

6. Hyperthermia in Veterinary Applications

• Mechanism: Gold nanorods are used for hyperthermia treatment in veterinary oncology, where they offer minimally invasive options for treating tumors in companion animals.
• Application Example: Nanopartz gold nanorods have been successfully used for treating spontaneous neoplasia in dogs through targeted hyperthermia.
• Research Reference: Schuh, Elizabeth M., et al. "Safety and Efficacy of Targeted Hyperthermia Treatment Utilizing Gold Nanorod Therapy in Spontaneous Canine Neoplasia." BMC Veterinary Research, 2017.

Benefits of Nanopartz In Vivo Gold Nanoparticles:

1. Biocompatibility: Nanopartz gold nanoparticles are biocompatible, reducing the likelihood of immune responses and ensuring safety in in vivo applications.
2. Long Circulation Times:
3. Enhanced Imaging: Their optical properties improve cancer diagnostics by providing clearer and more precise images in various diagnostic platforms.
4. Customizable Solutions: Our gold nanoparticles are customizable for specific applications in cancer research, therapeutics, and diagnostics, ensuring they meet the exact needs of your projects.

Why Choose Nanopartz for In Vivo Gold Nanoparticles?

• Proven Performance: Our nanoparticles have been used in multiple cancer research studies and clinical trials, providing reliable performance in both therapeutic and diagnostic contexts.
• Scalable Production: Nanopartz offers scalable nanoparticle solutions, from small-scale research to large-scale clinical applications, ensuring consistency and quality at every step.
• Trusted by Researchers: Nanopartz gold nanoparticles are trusted by top researchers globally for their quality and consistent results in cancer-related applications.

Nanopartz in vivo gold nanoparticles a subset of our overall offering of gold nanoparticles, are revolutionizing cancer therapeutics and cancer diagnostics by improving drug delivery, enhancing diagnostic imaging, and offering customizable solutions. Reach out to us today to explore how our nanoparticles can support your research or clinical trials.