Nanopartz In Vivo Gold Nanoparticles

At Nanopartz, we specialize in providing cutting-edge in vivo gold nanoparticles for cancer therapeutics and cancer diagnostics research. Our nanoparticles have been used in countless publications - designed to enhance drug delivery, improve cancer imaging, and facilitate early detection of tumors, making them ideal for advancing cancer research and clinical applications.


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Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to MDA-MB-435 tumors 72 hours after IV administration. (Nanopartz/MIT collaboration results)
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  • Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to MDA-MB-435 tumors 72 hours after IV administration. (Nanopartz/MIT collaboration results)
  • Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to soft tissue sarcoma tumors in canines 72 hours after IV administration. 10W 808nm laser was used for heating. (Nanopartz Clinical Trials)
  • Image of Nanopartz GNR labeled cell subsequently labeled with the live cell dye Calcein-AM, shown in red. From Motamedi 2011 BOE (2)5. NCBI Copyright Approval.
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Two photon image using low incident power of 1mW following intravenous injection of Nanopartz gold nanorods in Hamster Model showing blood vessels in the tissue. From Motamedi 2011 BOE (2) 5. NCBI Copyright Approved.
  • White light microscopy images of control tumor and GNS and Nanopartz Ntracker GNR injected mice. (Pink: cytoplasm stained with eosin, Dark Blue: nuclei stained with hematoxylin). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Tumor model (Green: cytoplasm stained with eosin, Yellow: GNSs and Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Nanopartz gold nanorod injected mice with nuclei staning (YOYO-1 iodide). Two photon IP image with FOV of 720x490um measured at the distance of approximately 100um inside the tumor edge. (Green: nuclei, Yellow: Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of Nanopartz gold nanorod injected mice with blood vessel staining (CD31 immunofluorescence staining). TPIP image with FOV of 790x520um. Red: blood vessels, Yellow: Nanopartz Ntracker Gold Nanorods. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of liver of Nanopartz Ntracker gold nanorod injected mice. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • In vivo imaging of single gold nanorods in mice ear blood vessels. Overlay of transmission image (light blue) and a single frame TPL image. Two single nanorods (red spots) are superimposed by a linescan (white). From Wei Nanomedicine (Lond). 2007 February 2(1) 125-132. NCBI Copyright Approval.
  • B Mode and photoacoustic images of subcutaneous tumor before and 2 minutes after a 200uL bolus of Nanopartz gold nanorods. Photoacoustic contrast in enhanced by gold nanorods in vasculature. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised spleen of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse spleen. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 970nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Gold nanorod contrast enhanced Optical Coherence Tomography images of a human breast carcinoma tissue sample. The sturcutral OCT image is presented in red, and the SOCT computed GNR density is presented in green.

Nanopartz™ gold nanoparticles for in vivo include both the Ntracker™ and Ntherapy™ family of nanorods, along with customer defined oligo and antibody conjugated nanrods for in vivo applications. The Ntracker™ non reactive methyl terminated nanorods are coated in a proprietary dense layer of hydrophilic polymers that shield the gold surface and give the particles ultra-long circulation times. Ntherapy™ nanorods come with similar hydrophilic polymers, but with terminal amine and carboxyl active groups, along with a number of custom popular in vivo targeting ligands. Ntherapy™ also provides an opportunity for the customer to define their own targeting ligands utilizing Nanopartz™ nanorod and polymer technologies. In this family, Nanopartz™ has the ability to covalently conjugate to specific antibody locations, thereby for example, leaving necessary primary amines exposed for optimum activity. The combination of the highly monodisperse Nanopartz™ gold nanorods with the proprietary Nanopartz™ polymers increase circulation times 50% longer than other commercial polymers thereby significantly improving targeting.

See our original publications for companion animal photothermal therapy here:

Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.

Schuh, Elizabeth M., et al. “Safety and Efficacy of Targeted Hyperthermia Treatment Utilizing Gold Nanorod Therapy in Spontaneous Canine Neoplasia.” BMC Veterinary Research, vol. 13, 2017, p. 294.

As opposed to other commercially available nanoparticles such as quantum dots, Nanopartz™ in vivo line of nanorods are completely non-toxic. Whereas Ntracker™ takes advantage of the Enhanced Permeability and Retention effect (EPR) for passive in vivo targeting, Ntherapy™ utilizes popular ligands for active targeting. This product line comes in a diameter of 10nm with SPRs matching all of the popular Near IR CW laser wavelengths; 780, 808, 850, 980, and 1064nm. Ntherapy™ offers options for oligo and customer detailed conjugations. Every batch is radiation sterilized in PBS, and comes with instructions for in vivo mouse iv injection. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data. Every product is in stock (99%) and is shipped next day for many ligands. This product comes in two concentrations, regular 1.75mg/mL, and highly concentrated 10mg/mL.

Applications of In Vivo Gold Nanoparticles in Cancer Therapeutics, Imaging and Diagnostics:

Nanopartz in vivo gold nanoparticles are used in a variety of applications that significantly impact cancer treatment and diagnostic procedures:

Nanopartz in vivo gold nanoparticles have several significant applications in cancer therapeutics, imaging, and diagnostics due to their unique optical, thermal, and biocompatible properties. Below are the key applications:

1. Photothermal Cancer Therapy

  • Mechanism: Gold nanoparticles (especially gold nanorods) absorb near-infrared light and convert it into heat, effectively destroying cancer cells through localized hyperthermia.
  • Application Example: Nanopartz gold nanorods have been used in photo-thermal cancer therapy to selectively heat and destroy tumors without damaging surrounding healthy tissue.
  • Research Reference: Fourkal, E., et al. "Photo-Thermal Cancer Therapy Using Gold Nanorods." World Congress on Medical Physics and Biomedical Engineering, Springer, 2009; Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.

2. Targeted Drug Delivery

  • Mechanism: Functionalized gold nanoparticles can carry therapeutic agents directly to cancer cells, increasing the efficacy of treatment while minimizing side effects.
  • Targeted Ligands: Nanoparticles can be conjugated with targeting ligands like antibodies, peptides, or folate, which bind to specific receptors overexpressed by cancer cells (e.g., EGFR, folate receptors).
  • Application Example: Gold nanoparticles are engineered for precise delivery to tumor sites, where they release the drugs under specific stimuli like light or pH change.

3. Imaging and Diagnostics

  • Optical Imaging: Gold nanoparticles, including gold nanorods and core-shell nanoparticles, enhance contrast in various imaging modalities such as Optical Coherence Tomography (OCT) and Surface-Enhanced Raman Scattering (SERS).
  • Application Example: Nanopartz gold nanoparticles are used for imaging tumor progression and metastatic tracking. Fluorescently-labeled gold nanoparticles can be used in vivo for micro-CT and optical projection tomography.
  • Research Reference: Kozomara, S. "Assessment of Fluorescently-Labeled Gold Nanoparticles in Mice as a Contrast Agent for Micro-Computed Tomography and Optical Projection Tomography." University of British Columbia, 2019.

4. Biodistribution and Cellular Uptake Studies

  • Mechanism: Understanding how gold nanoparticles distribute in the body and their interaction with cancer cells helps improve therapeutic delivery and imaging efficiency.
  • Application Example: Nanopartz gold nanoparticles are used in studies to track their distribution in tumors and organs, enabling optimization of dosage and targeting strategies.
  • Research Reference: Janát-Amsbury, M. M., et al. "Geometry and Surface Characteristics of Gold Nanoparticles Influence Their Biodistribution and Uptake by Macrophages." European Journal of Pharmaceutics and Biopharmaceutics, 2011.

5. Photodynamic Therapy (PDT)

  • Mechanism: In combination with photosensitizers, gold nanoparticles can be used in photodynamic therapy, where light activation leads to the generation of reactive oxygen species (ROS) that kill cancer cells.
  • Application Example: Nanopartz gold nanoparticles, functionalized with photosensitizers, enhance the efficacy of photodynamic therapy for solid tumors.

6. Hyperthermia in Veterinary Applications

  • Mechanism: Gold nanorods are used for hyperthermia treatment in veterinary oncology, where they offer minimally invasive options for treating tumors in companion animals.
  • Application Example: Nanopartz gold nanorods have been successfully used for treating spontaneous neoplasia in dogs through targeted hyperthermia.
  • Research Reference: Schuh, Elizabeth M., et al. "Safety and Efficacy of Targeted Hyperthermia Treatment Utilizing Gold Nanorod Therapy in Spontaneous Canine Neoplasia." BMC Veterinary Research, 2017.

Benefits of Nanopartz In Vivo Gold Nanoparticles:

  1. Biocompatibility: Nanopartz gold nanoparticles are biocompatible, reducing the likelihood of immune responses and ensuring safety in in vivo applications.
  2. Long Circulation Times:
  3. Enhanced Imaging: Their optical properties improve cancer diagnostics by providing clearer and more precise images in various diagnostic platforms.
  4. Customizable Solutions: Our gold nanoparticles are customizable for specific applications in cancer research, therapeutics, and diagnostics, ensuring they meet the exact needs of your projects.

Why Choose Nanopartz for In Vivo Gold Nanoparticles?

  • Proven Performance: Our nanoparticles have been used in multiple cancer research studies and clinical trials, providing reliable performance in both therapeutic and diagnostic contexts.
  • Scalable Production: Nanopartz offers scalable nanoparticle solutions, from small-scale research to large-scale clinical applications, ensuring consistency and quality at every step.
  • Trusted by Researchers: Nanopartz gold nanoparticles are trusted by top researchers globally for their quality and consistent results in cancer-related applications.

Nanopartz in vivo gold nanoparticles a subset of our overall offering of gold nanoparticles, are revolutionizing cancer therapeutics and cancer diagnostics by improving drug delivery, enhancing diagnostic imaging, and offering customizable solutions. Reach out to us today to explore how our nanoparticles can support your research or clinical trials.

 

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Product Specifications

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Part #D11 Nanopartz in vivo Spherical Gold Nanoparticles

Diameter (nm)
Peak SPR Wavelength (nm)
NPS/ml
Molarity (pM)
Moles
Molar Ext. (M-1cm-1)
Absorption Molar Ext. (M-1cm-1)
Scattering Molar Ext. (M-1cm-1)
Size Dispersity %PDI
Size Accuracy (+/- nm)
1.8
n/a
4.25E+16
7.10E+07
7.09E-08
7.05E+05
7.05E+05
0.00E+00
<35%
0.1
2.2
n/a
2.33E+16
3.90E+07
3.88E-08
1.29E+06
1.29E+06
0.00E+00
<25%
0.1
3
n/a
9.19E+15
1.50E+07
1.53E-08
3.26E+06
3.26E+06
0.00E+00
<20%
0.1
4
n/a
3.88E+15
6.50E+06
6.46E-09
7.74E+06
7.74E+06
0.00E+00
<20%
1
5
512
1.99E+15
3.30E+06
3.31E-09
1.51E+07
1.51E+07
0.00E+00
<20%
2
10
516
2.48E+14
4.10E+05
4.14E-10
1.21E+08
1.21E+08
0.00E+00
<15%
2
15
518
7.35E+13
1.20E+05
1.23E-10
4.08E+08
4.08E+08
0.00E+00
<15%
2
20
520
3.10E+13
5.20E+04
5.17E-11
9.67E+08
9.67E+08
0.00E+00
<10%
2
25
521
1.59E+13
2.60E+04
2.65E-11
1.89E+09
1.89E+09
0.00E+00
<10%
2
30
523
9.19E+12
1.50E+04
1.53E-11
3.26E+09
3.26E+09
0.00E+00
<6%
2
35
526
5.79E+12
9.60E+03
9.65E-12
5.18E+09
5.18E+09
0.00E+00
<6%
2
40
527
3.88E+12
6.50E+03
6.46E-12
7.74E+09
7.72E+09
2.24E+07
<4%
2
45
529
2.72E+12
4.50E+03
4.54E-12
1.10E+10
1.08E+10
2.03E+08
<4%
2
50
531
1.99E+12
3.30E+03
3.31E-12
1.51E+10
1.45E+10
5.88E+08
<4%
2
55
533
1.49E+12
2.50E+03
2.49E-12
2.01E+10
1.88E+10
1.30E+09
<4%
2
60
536
1.15E+12
1.90E+03
1.91E-12
2.61E+10
2.36E+10
2.48E+09
<4%
2
65
539
9.04E+11
1.50E+03
1.51E-12
3.32E+10
2.89E+10
4.33E+09
<4%
2
70
542
7.23E+11
1.20E+03
1.21E-12
4.15E+10
3.44E+10
7.09E+09
<4%
2
75
545
5.88E+11
9.80E+02
9.80E-13
5.10E+10
4.00E+10
1.10E+10
<4%
2
80
549
4.85E+11
8.10E+02
8.08E-13
6.19E+10
4.54E+10
1.65E+10
<4%
2
85
553
4.04E+11
6.70E+02
6.73E-13
7.42E+10
5.03E+10
2.39E+10
<4%
2
90
558
3.40E+11
5.70E+02
5.67E-13
8.81E+10
5.44E+10
3.37E+10
<4%
2
95
563
2.89E+11
4.80E+02
4.82E-13
1.04E+11
5.72E+10
4.65E+10
<4%
2
100
569
2.48E+11
4.10E+02
4.14E-13
1.21E+11
5.82E+10
6.27E+10
<4%
2
150
612
7.35E+10
1.20E+02
1.23E-13
4.08E+11
0.00E+00
4.08E+11
<4%
10
200
n/a
3.10E+10
5.20E+01
5.17E-14
9.67E+11
0.00E+00
9.67E+11
<4%
10
500
n/a
1.99E+09
3.30E+00
3.31E-15
1.51E+13
0.00E+00
1.51E+13
<4%
50
1000
n/a
2.48E+08
4.10E-01
4.14E-16
1.21E+14
0.00E+00
1.21E+14
<4%
100
1500
n/a
7.35E+07
1.20E-01
1.23E-16
4.08E+14
0.00E+00
4.08E+14
<4%
100

 

Optical Density >= 50, 5 for sizes >=500nm
Wt conc = 2.5mg/mL, 1mL volume typical
Wt % = 0.25%
ppm = 2500
%PDI = Std Dev/Size
See Tech Note TN801 for definition of terms and method of analysis
All specs typical. May vary batch to batch. Exact values are measured for each batch
Shape monodispersity (% spheres) > 99.9%
Solution default is 18MEG DI water
Residual Chemicals < 0.1%

 

 

Part #D12 Nanopartz in vivo Gold Nanorods

Diameter (nm)
Length (nm)
Peak SPR Wave (nm)
Aspect Ratio
OD SPR (AU)
Peak LSPR Wave (nm)
OD LSPR (AU)
Nanorods /mL
Wt. conc (ug/ml)
Wt. %
PPM
Molarity (nM)
Picomoles
SPR Molar Ext. (M-1cm-1)
LSPR Molar Ext. (M-1cm-1)

Peak SPR

(nm)
SPR Linewidth 80% (nm)
5
21
808
4.2
50
510
10
2.39E+14
1750
0.18%
1750
398.72
3.99E+02
1.25E+08
2.51E+07
794-829
100
5
19
780
3.8
50
510
10
2.67E+14
1750
0.18%
1750
444.72
4.45E+02
1.12E+08
2.25E+07
765-794
100
5
15
700
3
50
510
10
3.47E+14
1750
0.18%
1750
578.14
5.78E+02
8.65E+07
1.73E+07
675-725
100
10
175
2100
17.5
50
510
10
6.73E+12
1750
0.18%
1750
11.21
1.12E+01
4.46E+09
8.92E+08
1900-2300
300
10
102
1400
10.2
50
510
10
1.17E+13
1750
0.18%
1750
19.47
1.95E+01
2.57E+09
5.14E+08
1300-1500
150
10
81
1200
8.1
50
510
10
1.48E+13
1750
0.18%
1750
24.67
2.47E+01
2.03E+09
4.05E+08
1132-1300
150
10
67
1064
6.7
50
510
10
1.81E+13
1750
0.18%
1750
30.13
3.01E+01
1.66E+09
3.32E+08
1022-1132
150
10
59
980
5.9
50
510
10
2.09E+13
1750
0.18%
1750
34.91
3.49E+01
1.43E+09
2.86E+08
965-1022
150
10
55
950
5.5
50
510
10
2.22E+13
1750
0.18%
1750
37
3.70E+01
1.35E+09
2.70E+08
925-965
150
10
50
900
5
50
510
10
2.47E+13
1750
0.18%
1750
41.11
4.11E+01
1.22E+09
2.43E+08
875-925
150
10
45
850
4.5
50
510
10
2.78E+13
1750
0.18%
1750
46.25
4.63E+01
1.08E+09
2.16E+08
829-875
100
10
41
808
4.1
50
510
10
3.10E+13
1750
0.18%
1750
51.68
5.17E+01
9.68E+08
1.94E+08
794-829
75
10
38
780
3.8
50
510
10
3.36E+13
1750
0.18%
1750
56.06
5.61E+01
8.92E+08
1.78E+08
765-794
65
10
35
750
3.5
50
510
10
3.70E+13
1750
0.18%
1750
61.67
6.17E+01
8.11E+08
1.62E+08
725-765
50
10
29
700
2.9
50
510
10
4.44E+13
1750
0.18%
1750
74
7.40E+01
6.76E+08
1.35E+08
675-725
40
10
24
650
2.4
50
510
10
5.55E+13
1750
0.18%
1750
92.5
9.25E+01
5.41E+08
1.08E+08
625-675
40
10
19
600
1.9
50
510
10
7.40E+13
1750
0.18%
1750
123.34
1.23E+02
4.05E+08
8.11E+07
575-625
40
25
245
1400
9.8
50
514
15
1.12E+12
2500
0.25%
2500
1.86
1.86E+00
2.69E+10
8.06E+09
1232-1500
150
25
137
1064
5.5
50
514
15
2.05E+12
2500
0.25%
2500
3.42
3.42E+00
1.46E+10
4.38E+09
1022-1232
150
25
119
980
4.8
50
514
15
2.39E+12
2500
0.25%
2500
3.98
3.98E+00
1.26E+10
3.77E+09
965-1022
150
25
102
950
4.1
50
514
15
2.82E+12
2500
0.25%
2500
4.7
4.70E+00
1.06E+10
3.19E+09
925-965
150
25
96
900
3.8
50
514
15
3.01E+12
2500
0.25%
2500
5.02
5.02E+00
9.95E+09
2.99E+09
875-925
150
25
93
850
3.7
50
514
15
3.12E+12
2500
0.25%
2500
5.2
5.20E+00
9.61E+09
2.88E+09
829-875
150
25
90
808
3.6
50
514
15
3.24E+12
2500
0.25%
2500
5.39
5.39E+00
9.27E+09
2.78E+09
794-829
150
25
87
780
3.5
50
514
15
3.36E+12
2500
0.25%
2500
5.6
5.60E+00
8.93E+09
2.68E+09
765-794
150
25
85
750
3.4
50
514
15
3.45E+12
2500
0.25%
2500
5.75
5.75E+00
8.70E+09
2.61E+09
725-765
65
25
75
700
3
50
514
15
3.96E+12
2500
0.25%
2500
6.61
6.61E+00
7.57E+09
2.27E+09
675-725
60
25
71
650
2.8
50
514
15
4.22E+12
2500
0.25%
2500
7.03
7.03E+00
7.11E+09
2.13E+09
625-675
60
25
57
600
2.3
50
514
15
5.43E+12
2500
0.25%
2500
9.05
9.05E+00
5.52E+09
1.66E+09
575-625
60
25
34
550
1.4
50
514
15
1.01E+13
2500
0.25%
2500
16.91
1.69E+01
2.96E+09
8.87E+08
525-575
60
40
208
850
5.2
50
520
20
5.30E+11
2500
0.25%
2500
0.88
8.84E-01
5.66E+10
2.26E+10
1022-1232
150
40
180
850
4.5
50
520
20
6.19E+11
2500
0.25%
2500
1.03
1.03E+00
4.84E+10
1.94E+10
875-1022
150
40
148
850
3.7
50
520
20
7.67E+11
2500
0.25%
2500
1.28
1.28E+00
3.91E+10
1.57E+10
829-875
150
40
134
808
3.4
50
520
20
8.56E+11
2500
0.25%
2500
1.43
1.43E+00
3.51E+10
1.40E+10
794-829
150
40
124
780
3.1
50
520
20
9.33E+11
2500
0.25%
2500
1.55
1.55E+00
3.22E+10
1.29E+10
765-794
150
40
112
750
2.8
50
520
20
1.05E+12
2500
0.25%
2500
1.74
1.74E+00
2.87E+10
1.15E+10
725-765
150
40
92
700
2.3
50
520
20
1.31E+12
2500
0.25%
2500
2.19
2.19E+00
2.29E+10
9.14E+09
675-725
60
40
80
650
2
50
520
20
1.55E+12
2500
0.25%
2500
2.58
2.58E+00
1.94E+10
7.75E+09
625-675
60
40
68
600
1.7
50
520
20
1.89E+12
2500
0.25%
2500
3.15
3.15E+00
1.59E+10
6.35E+09
575-625
60
40
60
550
1.5
50
520
20
2.21E+12
2500
0.25%
2500
3.69
3.69E+00
1.36E+10
5.42E+09
525-575
60
50
245
1064
4.9
50
530
25
2.89E+11
2500
0.25%
2500
0.48
4.82E-01
1.04E+11
5.18E+10
980-1232
150
50
145
808
2.9
50
530
25
5.15E+11
2500
0.25%
2500
0.86
8.58E-01
5.83E+10
2.91E+10
750-850
150
50
110
700
2.2
50
530
25
7.08E+11
2500
0.25%
2500
1.18
1.18E+00
4.24E+10
2.12E+10
650-750
150
50
100
600
2
50
530
25
7.93E+11
2500
0.25%
2500
1.32
1.32E+00
3.78E+10
1.89E+10
550-650
150
70
120
750
1.7
50
530
25
3.49E+11
2500
0.25%
2500
0.58
5.81E-01
8.60E+10
4.30E+10
700-800
150
70
105
650
1.5
50
530
25
4.13E+11
2500
0.25%
2500
0.69
6.88E-01
7.27E+10
3.63E+10
600-700
150
70
91
550
1.3
50
530
25
4.98E+11
2500
0.25%
2500
0.83
8.30E-01
6.02E+10
3.01E+10
500-600
150

 

Optical Density >= 50, volume = 1mL
All specs typical. May vary batch to batch. Exact values are measured for each batch
Solution default is 18MEG DI water
Residual Chemicals < 0.1%

 

 

Functionalizations

Functionalized Nanorod Block Invitro

 

Functionalized gold nanoparticle with Nanopartz™ long circulating polymer. Thickness of polymer is 1-2nm.

 

Ligand Application Reference
PEG (Polyethylene Glycol) Prolongs circulation time, reduces immune response, stem cell tracking, and drug delivery Nanopartz. “NANOPARTZ-AuNS-50-25: 50 nm PEGylated Gold Nanoparticles.” Nanopartz.com, 2022.
Amine-functionalized ligands Enhanced cellular uptake and neural stem cell tracking in vivo Nanopartz. “NANOPARTZ-AuNS-30-12: 30 nm Amine-Functionalized Gold Nanoparticles.” Nanopartz.com, 2021.
Carboxyl-functionalized ligands Tumor-targeted drug delivery and cancer treatment Nanopartz. “NANOPARTZ-AuNS-20-6: 20 nm Carboxyl-Functionalized Gold Nanoparticles.” Nanopartz.com, 2020.
A33scFv (Single Chain Variable Fragment) Targets colorectal cancer cells for imaging and treatment Osborn, Matthew J., et al. “Colorectal Cancer Therapy with A33scFv-Conjugated Gold Nanoparticles.” Clinical Cancer Research, vol. 19, no. 10, 2013, pp. 2828-2837.
Chitosan Gene delivery, enhanced stability, and tumor targeting Zhang, Jie, et al. “Chitosan-Coated Gold Nanoparticles for Enhanced Gene Delivery and Stability.” International Journal of Nanomedicine, vol. 11, 2016, pp. 3925-3936.
Anti-EGFR (Epidermal Growth Factor Receptor) Targeted cancer therapy and imaging of EGFR-expressing tumors Wang, Hong, et al. “Anti-EGFR Antibody-Conjugated Gold Nanoparticles for Enhanced Cancer Imaging.” ACS Nano, vol. 8, no. 9, 2014, pp. 9874-9883.
Folate Targets folate receptor-expressing cancer cells for imaging and treatment Nanopartz. “NANOPARTZ-AuNS-35-10: 35 nm Folate-Functionalized Gold Nanoparticles.” Nanopartz.com, 2019.
CD33 Targets acute myeloid leukemia (AML) cells Lou, Yifu, et al. “Targeting CD33 with Gold Nanoparticles in Acute Myeloid Leukemia.” Leukemia Research, vol. 45, 2015, pp. 55-61.
CD24 Tracking and targeting cancer stem cells in vivo Kim, Hyun, et al. “CD24-Targeted Gold Nanoparticles for Cancer Stem Cell Therapy.” Oncotarget, vol. 9, no. 12, 2018, pp. 9852-9864.
CD45 Hematopoietic stem cell tracking in vivo Driessen, Willem J., et al. “CD45-Targeted Gold Nanoparticles for Hematopoietic Stem Cell Tracking.” Blood, vol. 114, no. 12, 2009, pp. 2454-2462.
EPCAM (Epithelial Cell Adhesion Molecule) Targeted imaging and therapy for epithelial cancers Nanopartz. “NANOPARTZ-AuNS-45-18: 45 nm EPCAM-Functionalized Gold Nanoparticles.” Nanopartz.com, 2020.
T-cells Immunotherapy and tracking engineered T-cells in vivo Alkilany, Alaaldin M., et al. “Gold Nanoparticles for Tracking Engineered T-Cells in Cancer Immunotherapy.” Advanced Drug Delivery Reviews, vol. 143, 2019, pp. 113-120.
CD4 Imaging and tracking CD4+ T-cells in HIV research Chen, X., et al. “CD4-Targeted Gold Nanoparticles for HIV Therapy and Tracking.” Nature Medicine, vol. 23, no. 5, 2017, pp. 685-690.
PEI (Polyethyleneimine) Gene delivery and transfection efficiency in cancer therapy Thomas, Mike, et al. “PEI-Coated Gold Nanoparticles for Improved Gene Therapy.” Gene Therapy, vol. 12, no. 10, 2005, pp. 810-817.
Gold Nanorods Photothermal cancer therapy Fourkal, E., et al. “Photo-Thermal Cancer Therapy Using Gold Nanorods.” World Congress on Medical Physics and Biomedical Engineering, Springer, 2009.
Gold Nanorods Computationally guided photothermal tumor therapy Von Maltzahn, G., et al. “Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas.” Cancer Research, vol. 69, no. 9, 2009, pp. 3892-3900.
Gold-Silver Core-Shell Enhanced photothermal effects and excited-state dynamics Karam, T.E., et al. “Enhanced Photothermal Effects and Excited-State Dynamics of Plasmonic Size-Controlled Gold–Silver–Gold Core–Shell–Shell Nanoparticles.” The Journal of Physical Chemistry C, vol. 119, no. 22, 2015, pp. 12988-12998.
Gold Nanoparticles Ultrafast photothermal release of DNA Thibaudau, F. “Ultrafast Photothermal Release of DNA from Gold Nanoparticles.” The Journal of Physical Chemistry Letters, vol. 3, no. 11, 2012, pp. 1270-1275.
Gold Nanorods Hyperthermia treatment in canine neoplasia Schuh, Elizabeth M., et al. “Safety and Efficacy of Targeted Hyperthermia Treatment Utilizing Gold Nanorod Therapy in Spontaneous Canine Neoplasia.” BMC Veterinary Research, vol. 13, 2017, p. 294.
Gold Nanorods Applications in cancer therapy and in vivo imaging in animals and humans Schoen, Christian, and Cheryl London. “Pandia: Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans.” Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, Wiley, 2014.

 

Properties, Tech Notes, SDS, Storage and Handling

≡

Details

Composition

These polymer coated gold nanoparticles are shipped in PBS with no measurable residual chemicals. This product is radiation sterilized and is ready for injection.

Custom Formulation

Popular CW laser wavelengths for the nanorods are available (780, 808, 850, 980, and 1064nm). 

Quantity

This product is available in 1mL and larger but in two different concentrations. The lower concentration is suited for mice, while the higher concentration is suitable for companion animals. For mice, the 1mL injection is suited for 5 injections. For orders larger than 1L, or for orders amounting over 10L per annum, please contact sales for quantity pricing.

Delivery

Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays.

Conjugation

This product comes coated with a proprietary polymer to increase circulation times.

Introductory Kits

Unfortunately there are no kits available for this product at this time.

Shelf Life/Storage Temperature

This product is guaranteed for one year and may be stored at room temperature.

Toxicity

These products are non cytotoxic.

Sterilization

This product is sterilized.

Certifications

This product is manufactured using our audited ISO 9000/2001 quality control system. Every order comes with a Certification of Analysis that includes the following information. We use NIST traceable:

UV-VIS (Agilent 8453) for extinction and concentration measurements

NIR (Cary 500) for NIR extinction and concentration measurements

DLS (Malvern Nano ZS) for zeta potential measurement

ICP-MS (Varian 820-MS) for gold mass measurements

TEM (Phillips CM-100 100KV) for sizing

UV VIS

Spherical Gold Nanoparticles UV VIS

Tech Notes, SDS, S/H

FAQz, Testimonials, Publications

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FAQz

How much thickness does your proprietary ligand add?

Anywhere from 1-2nm.

What about PEG? What is its length?

Click on the link to the PEG Length Technical Note.

How do I determine the concentration of the product?

Simply divide the number of nanoparticles (nps) found on the included COA by the amount of solution you add.

Why do you sell your rods as OD-mLs and what does this mean?

This is because unlike spherical gold nanoparticles, the conversion from OD to mg is not linear with nanorod diameter. Consequently, for the same OD, the weight of the nanorods increases with diameter. 50 OD-mLs means that if you resuspend the material in 1mL of solvent, you will have an absorption of OD50 through a 1mL optical path.

Can I resuspend in water?

Yes

What is the shelf life if I never open the package and keep refrigerated?

Many years.

Should I store in the refrigerator?

Yes.

How do you size your gold nanoparticles? Does the size include the capping agent?

We use three methods to specify our gold nanoparticles; TEM, UV VIS, and DLS. Each has its own advantages and disadvantages, and we use a weighted system to take advantage of each methods strengths. In the end, we place the strongest weight to the TEM method, particularly since we use samples sizes greater than 50 particles for each lot.

Do you really provide a TEM for my specific lot?

Yes, and not just for 5-10 particles, rather 50-100 are standard.

What is OD?

Optical Density (OD) is measured by UV-VIS. An Optical Density OD=1 corresponds to a transmission of 10% through a 1cm cuvette. Optical Density is a nice unit to use since Optical Densities correlate linearly to concentration. So an Optical Density of 1.2 is equal to 1.2 times the concentration of a gold nanoparticle solution that has an Optical Density of 1. We use OD and concentration interchangingly as it is easier to refer to a solution of OD=1 rather than 2.35e12 nanoparticles. For all spheres up to 200nm, OD=1 does refer to 0.05mg/mL.

What is PDI?

PDI refers to polydispersity index and is equal to the standard deviation of the particle sizes divided by the average size.

How does your polymer bridge compare to PEG?

It is superior in its resistance to salt, pH, and other chemicals.

Testimonials

"We have looked at many different gold nanoparticles samples from Nanopartz including spheres, rods, and microrods using single particle spectroscopy techniques and are extremely happy with the quality of the samples and the service provided by Nanopartz."

Stephan Link, PhD
Assistant Professor of Chemistry
Rice University

Publications

  • Labens, R., B. D. X. Lascelles, and A. N. Charlton. "Ex Vivo Effect of Gold Nanoparticles on Porcine Synovial Membrane." Tissue Engineering and Regenerative Medicine, 2013, Taylor & Francis.

  • Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.

  • Janát-Amsbury, M. M., A. Ray, and C. M. Peterson. "Geometry and Surface Characteristics of Gold Nanoparticles Influence Their Biodistribution and Uptake by Macrophages." European Journal of Pharmaceutics and Biopharmaceutics, 2011, Elsevier.

  • Naha, P. C., P. Chhour, and D. P. Cormode. "Systematic in Vitro Toxicological Screening of Gold Nanoparticles Designed for Nanomedicine Applications." Toxicology in Vitro, 2015, Elsevier.

  • Kozomara, S. "Assessment of Fluorescently-Labeled Gold Nanoparticles in Mice as a Contrast Agent for Micro-Computed Tomography and Optical Projection Tomography." University of British Columbia, 2019. open.library.ubc.ca.

  • Kozomara, S., and N. L. Ford. "Imaging of Murine Melanoma Tumors Using Fluorescent Gold Nanoparticles." Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, SPIE, 2019.

  • Kozomara, S., and N. L. Ford. "Detectability of Fluorescent Gold Nanoparticles Under Micro-CT and Optical Projection Tomography Imaging." Journal of Medical Imaging, 2020, spiedigitallibrary.org.

  • Galanzha, E. I., E. Shashkov, M. Sarimollaoglu, and V. P. Zharov. "In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles." PLOS ONE, 2012.

  • Boyoglu, C., Q. He, and G. Willing. "Microscopic Studies of Various Sizes of Gold Nanoparticles and Their Cellular Localizations." International Journal of Nanomedicine, 2013, Wiley Online Library.

  • Li, W. B., S. Stangl, A. Klapproth, M. Shevtsov, and T. Multhoff. "Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy—Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect." Cancers, 2021, MDPI.

Technology

≡

Background

The manufacturing method for these nanoparticles are based on our proprietary method. This family of products have resulted in hundreds ofpublications and is the cornerstone of our product line.

Technology Comparison

 

 

  Nanopartz™ in vivo Gold Nanoparticles Other Polymers like PEG Gold Nanoparticles
Stability (salt,pH,chemicals) High Medium
Monovalent Yes No
Nonspecific binding Very low Medium
Sterilization Yes No
Circulation Time Long Low
Toxicity None Broad
Photothermal efficiency Highest recorded Low
Imaging potential Yes Very Limited
Drug Delivery potential Yes Very Limited
Tumor Loading High Low

Features and Benefits

  • Covalent bonds insure specificity, stability, long shelf life
  • Buffer Stability - stable from pH 4-9
  • No sodium azide
  • No BSA
  • Polymer coating insures no aggregation in high salts, reduced nonspecific binding
  • Stable
  • Well Characterized
  • Customer can select buffer
  • Customer can select gold nanoparticle type, size and/or SPR
  • Loading of all ligands is optimized

Part Numbers, How to Order

Example part number is D12-10-808-VM-DIH-50-1-CS-EP where:

D12 - Product family number for in vivo gold nanorods

10-808 - Diameter and SPR of nanorod

VM - in vivo long circulating methyl polymer

DIH - Buffer, in this case 18MEG DI water. Other choices are PBS, MES, Sodium Borate, TRIS

50 - Optical Density, in this case OD=50, optional 250

1 - Volume (mL). Other choices are 5mL, 10mL and more.

CS - Certified Sterilized - Though the product come sterilized, this option includes testing and certification.

EP - Endotoxin Purified - The product is endotoxin purified and certified.

How to Order

Ordering by scrolling down and selecting the options from the selection below.

 

Home
» D- In Vivo Gold Nanoparticles
» D- Conjugated Gold Nanoparticles for In Vivo
Functionallized Spherical Gold Nanoparticles for in vivo
Functionallized Spherical Gold Nanoparticles for in vivo
Part Number: D11
Options: (DIAMETER)-(FUNCTIONALIZATION)-SAL-(OD-mLs)-(VOL)-CS-EP-NC
Example Part Number: 30nm diameter spherical gold nanoparticle, CD45, 18MEG Saline, 50 OD (2.5mg), in 1mL, Endotoxin Purified, and 0.1mL Negative Control
D11-30-VACD45-SAL-50-1-EP-0.1NC

UV-VIS

OD-mLs = Optical Density x mLs
50 OD-mLs = 2.5mg Au
250 OD-mL = 12.5mg Au
Price$1,020.00
Functionalized Gold Nanorods for in vivo
Functionalized Gold Nanorods for in vivo
Part Number: D12
Options: (DIAM-SPR)-(FUNCTIONALIZATION)-SAL-(OD-mLs)-(VOL)-CS-EP-NC
Example Part Number: 10x45nm diameter gold nanorod with SPR=850nm, anti EGFR polymer, Saline, 50 OD (2.5mg), in 1mL, Endotoxin Purified, and 0.1mL Negative Control
D12-10-850-EGFR-SAL-50-1-EP-0.1NC
OD-mLs = Optical Density x mLs
50 OD-mLs = 2.5mg Au
250 OD-mL = 12.5mg Au
Price$1,040.00