Advanced Gold Nanoparticle and Nanorod In Vivo Imaging Solutions by Nanopartz | Nanopartz™

Nanopartz is at the forefront of gold nanoparticles and nanorod in vivo imaging, offering cutting-edge technology designed for non-invasive, high-contrast imaging applications. These specialized nanoparticles and nanorods provide unparalleled imaging quality due to their strong absorption properties, making them ideal for in vivo imaging in fields such as cancer research, molecular biology, and cardiovascular studies


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Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to soft tissue sarcoma tumors in canines 72 hours after IV administration. 10W 808nm laser was used for heating. (Nanopartz Clinical Trials)
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  • Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to soft tissue sarcoma tumors in canines 72 hours after IV administration. 10W 808nm laser was used for heating. (Nanopartz Clinical Trials)
  • Nanopartz™ Nanorods™ were intratumorally given to mice bearing bilateral MDA-MB-435 tumors and imaged using X-ray CT to visualize three-dimensional distribution in tumors.
  • A three-dimensional solid model of the complete geometry was rapidly reconstructed by image processing for use with computational photothermal modeling.
  • Red, PEG-NRs. Experimental thermographic surveillance of NIR irradiation after X-ray CT (~0.75 W/cm2 , 1 min; bottom). From MIT/Nanopartz Collaboration 2009.
  • Photothermal imaging of passively targeted Nanopartz Ntracker nanorods to MDA-MB-435 tumors 72 hours after IV administration. (Nanopartz/MIT collaboration results)

  • Image of Nanopartz GNR labeled cell subsequently labeled with the live cell dye Calcein-AM, shown in red. From Motamedi 2011 BOE (2)5. NCBI Copyright Approval.
  • Two Photon Image of Nanopartz GNR labeled cells using an incident power of 0.7mW overlayed with corresponding transmitted light micrograph. From Motmaedi 2011 BOE(2)5. NCBI Copyright Approved.
  • Two photon image using low incident power of 1mW following intravenous injection of Nanopartz gold nanorods in Hamster Model showing blood vessels in the tissue. From Motamedi 2011 BOE (2) 5. NCBI Copyright Approved.
  • White light microscopy images of control tumor and GNS and Nanopartz Ntracker GNR injected mice. (Pink: cytoplasm stained with eosin, Dark Blue: nuclei stained with hematoxylin). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Tumor model (Green: cytoplasm stained with eosin, Yellow: GNSs and Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • TPIP images of Nanopartz gold nanorod injected mice with nuclei staning (YOYO-1 iodide). Two photon IP image with FOV of 720x490um measured at the distance of approximately 100um inside the tumor edge. (Green: nuclei, Yellow: Nanopartz Ntracker gold nanorods). From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of Nanopartz gold nanorod injected mice with blood vessel staining (CD31 immunofluorescence staining). TPIP image with FOV of 790x520um. Red: blood vessels, Yellow: Nanopartz Ntracker Gold Nanorods. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • Two Photon IP images of liver of Nanopartz Ntracker gold nanorod injected mice. From Park, Lasers Surg Med. 2010 September 42(7) 630. NCBI Copyright Approved.
  • In vivo imaging of single gold nanorods in mice ear blood vessels. Overlay of transmission image (light blue) and a single frame TPL image. Two single nanorods (red spots) are superimposed by a linescan (white). From Wei Nanomedicine (Lond). 2007 February 2(1) 125-132. NCBI Copyright Approval.
  • B Mode and photoacoustic images of subcutaneous tumor before and 2 minutes after a 200uL bolus of Nanopartz gold nanorods. Photoacoustic contrast in enhanced by gold nanorods in vasculature. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised spleen of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse spleen. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Ex vivo 3D photoacoustic images taken at 750nm of the excised liver of a mouse 1 day after a tail vein injection of 200uL of Nanopartz gold nanorods and a control mouse liver. From Visualsonics appliation note: Imaging of Nanoparticle Based Contrast Agents with Vevo LAZR Photoacoustic Imaging System. www.visualsonics.com
  • Gold nanorod contrast enhanced Optical Coherence Tomography images of a human breast carcinoma tissue sample. The sturcutral OCT image is presented in red, and the SOCT computed GNR density is presented in green.

Nanopartz™ in vivo long circulating nanorods are coated in a proprietary dense layer of hydrophilic polymers that shield the gold surface and give the particles ultra-long circulation times. The combination of the highly monodisperse Nanopartz™ gold nanorods with the proprietary Nanopartz™ polymers increase circulation times 50% longer than other commercial polymers thereby significantly improving targeting.

Product Options for In Vivo Imaging

Nanopartz offers an array of gold nanoparticle and nanorod products specifically for in vivo imaging applications. Each product is customizable in terms of size, shape, and functionalization, ensuring compatibility with various imaging systems. These products are optimized for use in photoacoustic imaging, optical coherence tomography, and other in vivo applications.

In Vivo Imaging Applications Using Gold Nanorods

Gold nanorods offer remarkable versatility in in vivo imaging applications, leveraging their unique optical properties, NIR absorption, and biocompatibility. Below are the primary imaging applications of gold nanorods.

1. Targeted Plasmonic Photothermal Immunotherapy (TPIP)

  • Application: TPIP combines imaging with localized photothermal therapy, selectively targeting and ablating cancer cells while stimulating an immune response.
  • Role of Gold Nanorods: Functionalized gold nanorods target cancer cells and convert NIR light into localized heat, destroying tumor cells and triggering immune activity. Nanopartz provides gold nanorods optimized for targeted delivery and controlled heating for TPIP.
  • Literature Reference: Nanopartz Gold Nanoparticles are used in Park, J., A. Estrada, J. A. Schwartz, et al. "Intra‐Organ Biodistribution of Gold Nanoparticles Using Intrinsic Two‐Photon‐Induced Photoluminescence." Lasers in Surgery and Medicine, vol. 42, no. 5, 2010, pp. 630-639. Wiley Online Library.

2. Photoacoustic Imaging

  • Application: This imaging technique uses laser-induced ultrasound to produce detailed images of internal tissue structures, commonly applied in cancer visualization and vascular studies.
  • Role of Gold Nanorods: Nanopartz gold nanorods enhance NIR absorption, generating an acoustic signal ideal for imaging deep tissues.
  • Literature Reference:
    • Nanopartz Gold Nanorods are used in Cui, H., and X. Yang. "In Vivo Imaging and Treatment of Solid Tumor Using Integrated Photoacoustic Imaging and High Intensity Focused Ultrasound System." Medical Physics, vol. 37, no. 9, 2010, pp. 4777-4782. Wiley Online Library
    • Song, K. H., C. Kim, K. Maslov, and L. V. Wang. "Noninvasive In Vivo Spectroscopic Nanorod-Contrast Photoacoustic Mapping of Sentinel Lymph Nodes." European Journal of Radiology, vol. 70, no. 2, 2009, pp. 227-231. Elsevier.

3. Optical Coherence Tomography (OCT)

  • Application: OCT is used for detailed cross-sectional imaging of tissues, especially in ophthalmology.
  • Role of Gold Nanorods: Gold nanorods increase contrast in OCT images, allowing detailed visualization of tissue structures.
  • Literature Reference: Nanopartz Gold Nanoparticles are used in Singh, R., J. C. Batoki, M. Ali, V. L. Bonilha, et al. "Inhibition of Choroidal Neovascularization by Systemic Delivery of Gold Nanoparticles." Biomaterials, Biology and Medicine, vol. 25, 2020, pp. 101-108. Elsevier.

4. Fluorescence Imaging

  • Application: Fluorescence imaging tags and tracks biological molecules within living tissues.
  • Role of Gold Nanorods: Functionalized Nanopartz gold nanorods provide strong and persistent fluorescence for enhanced imaging in molecular biology and cancer research.
  • Literature Reference: Nanopartz Gold Nanoparticles are used in
    • Kozomara, S. Assessment of Fluorescently-Labeled Gold Nanoparticles in Mice as a Contrast Agent for Micro-Computed Tomography and Optical Projection Tomography. 2019, University of British Columbia, open.library.ubc.ca.
    • Steve Kozomara, Nancy L. Ford, "Imaging of murine melanoma tumors using
      fluorescent gold nanoparticles," Proc. SPIE 10953, Medical Imaging 2019:
      Biomedical Applications in Molecular, Structural, and Functional Imaging,
      1095313 (15 March 2019); doi: 10.1117/12.2512298

5. Two-Photon Imaging

  • Application: Two-photon imaging provides high-resolution imaging of live tissues with minimal tissue damage, often used in neuroscience.
  • Role of Gold Nanorods: Nanopartz gold nanorods enhance two-photon absorption, improving imaging depth and resolution.
  • Literature Reference: Nanopartz Gold Nanoparticles are used in Park, J., A. Estrada, J. A. Schwartz, et al. "Intra‐organ Biodistribution of Gold Nanoparticles Using Intrinsic Two‐Photon‐Induced Photoluminescence." Lasers in Surgery and Medicine, vol. 42, no. 5, 2010, pp. 630-639. Wiley Online Library.

6. Raman Imaging (Surface-Enhanced Raman Scattering, SERS)

  • Application: Raman imaging provides molecular-level information, making it ideal for detecting chemical compositions.
  • Role of Gold Nanorods: Nanopartz gold nanorods amplify Raman signals, enhancing sensitivity in detecting molecular compositions.
  • Literature Reference:
    • Nanopartz Ramanprobes are used in Wang, Z., H. Ding, G. Lu, and X. Bi. "Use of a Mechanical Iris-Based Fiber Optic Probe for Spatially Offset Raman Spectroscopy." Optics Letters, vol. 39, no. 2, 2014, pp. 353-356. Optica Publishing Group
    • Von Maltzahn, G., A. Centrone, J. H. Park, et al. "SERS-Coded Gold Nanorods as a Multifunctional Platform for Densely Multiplexed Near-Infrared Imaging and Photothermal Heating." Advanced Functional Materials, vol. 19, no. 24, 2009, pp. 1-8. National Center for Biotechnology Information, ncbi.nlm.nih.gov.

7. Computed Tomography (CT) Imaging

  • Application: CT imaging is used to capture high-contrast images of anatomical structures.
  • Role of Gold Nanorods: Due to gold’s high atomic number, gold nanorods serve as effective contrast agents in CT scans.
  • Literature Reference: Nanopartz Materials are used in :
    • Kozomara, S. Assessment of Fluorescently-Labeled Gold Nanoparticles in Mice as a Contrast Agent for Micro-Computed Tomography and Optical Projection Tomography. 2019, University of British Columbia, open.library.ubc.ca.

    • Kozomara, S., and N. L. Ford. "Detectability of Fluorescent Gold Nanoparticles under Micro-CT and Optical Projection Tomography Imaging." Journal of Medical Imaging, vol. 7, no. 1, 2020, pp. 1-7. SPIE Digital Library, spiedigitallibrary.org.

    • Kozomara, S., and N. L. Ford. "Imaging of Murine Melanoma Tumors Using Fluorescent Gold Nanoparticles." Journal of Structural and Functional Imaging, 2019, spiedigitallibrary.org.

    • Kee, P. H., and D. Danila. "CT Imaging of Myocardial Scar Burden with CNA35-Conjugated Gold Nanoparticles." Nanomedicine: Nanotechnology, Biology and Medicine, vol. 14, no. 2, 2018, pp. 143-152. Elsevier.

    • Von Maltzahn, G., J. H. Park, A. Agrawal, N. K. Bandaru, et al. "Computationally Guided Photothermal Tumor Therapy Using Long-Circulating Gold Nanorod Antennas." Cancer Research, vol. 69, no. 9, 2009, pp. 3892-3900. American Association for Cancer Research (AACR).

    • Gehrmann, M. K., M. A. Kimm, S. Stangl, et al. "Imaging of Hsp70-Positive Tumors with cmHsp70.1 Antibody-Conjugated Gold Nanoparticles." International Journal of Hyperthermia, vol. 31, no. 7, 2015, pp. 690-701. Taylor & Francis.

8. Theranostic Imaging

  • Application: Theranostic imaging integrates diagnostics with therapy, providing real-time imaging during treatment.
  • Role of Gold Nanorods: Nanopartz gold nanorods offer simultaneous imaging and targeted photothermal therapy.
  • Literature Reference: Nanopartz Materials are used in:
    • Wang, Y., C. Xu, and H. Ow. "Commercial Nanoparticles for Stem Cell Labeling and Tracking." Theranostics, vol. 3, no. 8, 2013, pp. 544-560. National Center for Biotechnology Information, ncbi.nlm.nih.gov.

    • Lukianova-Hleb, E. Y., E. Y. Hanna, J. H. Hafner, et al. "Tunable Plasmonic Nanobubbles for Cell Theranostics." Nanotechnology, vol. 21, no. 8, 2010, pp. 1-10. IOP Science, iopscience.iop.org.

    • Galanzha, E. I., E. Shashkov, M. Sarimollaoglu, et al. "In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles." PLOS ONE, vol. 7, no. 4, 2012, pp. 1-12. PLOS, journals.plos.org.

    • Zhang, Z., M. Taylor, C. Collins, and S. Haworth. "Light-Activatable Theranostic Agents for Image-Monitored Controlled Drug Delivery." ACS Applied Materials & Interfaces, vol. 10, no. 1, 2018, pp. 514-522. American Chemical Society, ACS Publications.

9. Near-Infrared (NIR) Imaging

  • Application: NIR imaging provides deeper tissue imaging with minimal scattering, especially valuable in oncology.
  • Role of Gold Nanorods: Nanopartz gold nanorods, tuned for maximum NIR absorption, enable deeper and high-contrast imaging.
  • Literature Reference: Nanopartz materials are used in Pan, D., M. Pramanik, A. Senpan, et al. "A Facile Synthesis of Novel Self-Assembled Gold Nanorods Designed for Near-Infrared Imaging." Journal of Nanoscience and Nanotechnology, vol. 10, no. 8, 2010, pp. 1-8. Ingenta Connect, ingentaconnect.com.

10. Angiography and Blood Vessel Imaging

  • Application: Angiography visualizes blood vessels to detect abnormalities or occlusions.
  • Role of Gold Nanorods: Gold nanorods enhance vascular contrast, improving blood flow visualization and aiding in the diagnosis of vascular diseases.
  • Literature Reference: Nanopartz materials are used in Nguyen, V. P., Y. Li, J. Henry, W. Zhang, M. Aaberg, et al. "Plasmonic Gold Nanostar-Enhanced Multimodal Photoacoustic Microscopy and Optical Coherence Tomography Molecular Imaging to Evaluate Choroidal Neovascularization." ACS Nano, vol. 14, no. 12, 2020, pp. 1-10. American Chemical Society, ACS Publications.

Key Benefits of Nanopartz In Vivo Imaging Solutions

  • Enhanced Contrast: Gold nanoparticles and nanorods generate high-quality contrast in images, making it easier to identify specific structures and track biological processes.
  • Deep Tissue Penetration: Tunable optical properties allow for imaging at various depths within the body, making these particles suitable for advanced in vivo imaging techniques.
  • Biocompatibility: Nanopartz gold nanoparticles are designed for biocompatibility, minimizing risks in live tissue studies.

Why Choose Nanopartz Gold Nanoparticles and Nanorods for In Vivo Imaging?

Gold nanoparticles and nanorods excel in imaging because of their unique optical properties, which include tunable light absorption and scattering. These features enhance imaging contrast and allow for deeper tissue penetration, making them ideal for real-time imaging in living organisms. Nanopartz gold nanoparticles and nanorods are available in multiple customizable sizes and shapes to support a wide range of research and medical imaging needs.

Conclusion:

Nanopartz in vivo gold nanoparticles are revolutionizing cancer therapeutics and cancer diagnostics by improving drug delivery, enhancing diagnostic imaging, and offering customizable solutions. Reach out to us today to explore how our nanoparticles can support your research or clinical trials.

 

Go here for a complete listing of Nanopartz in vivo Gold Nanoparticle products that can be used for all of these imaging applications.