Gold Nanoparticles for Photothermal Therapeutics - NTracker™ by Nanopartz™
At Nanopartz, we specialize in gold nanoparticles engineered for advanced photothermal therapeutics, offering superior performance in precision treatments. Our NTracker™ gold nanoparticles are optimized for in vivo therapeutic applications, particularly in photothermal therapy, where targeted heating can destroy cancer cells while sparing healthy tissues.
Nanopartz™ Ntracker™ long circulating nanorods are coated in a proprietary dense layer of hydrophilic polymers that shield the gold surface and give the particles ultra-long circulation times. The combination of the highly monodisperse Nanopartz™ gold nanorods with the proprietary Nanopartz™ polymers increase circulation times 50% longer than other commercial polymers thereby significantly improving targeting.
See our original publications for companion animal photothermal therapy here:
Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.
Schuh, Elizabeth M., et al. “Safety and Efficacy of Targeted Hyperthermia Treatment Utilizing Gold Nanorod Therapy in Spontaneous Canine Neoplasia.” BMC Veterinary Research, vol. 13, 2017, p. 294.
As opposed to other commercially available nanoparticles such as quantum dots, Nanopartz™ in vivo line of nanorods are completely non-toxic. Ntracker™ takes advantage of the Enhanced Permeability and Retention effect (EPR) for passive in vivo targeting, This product line comes in a diameter of 10nm with SPRs matching all of the popular Near IR CW laser wavelengths; 780, 808, 850, 980, and 1064nm. Every batch is endotoxin purified, and comes with instructions for in vivo mouse iv injection. A Certificate of Analysis (COA) is provided for every order exhibiting TEM and UV-VIS images and data, as well as DLS data. Every product is in stock (99%) and is shipped next day for many ligands. This product comes in two concentrations, regular 1.75mg/mL, and highly concentrated 10mg/mL.
Applications of In Vivo Gold Nanoparticles in Cancer Therapeutics, Imaging and Diagnostics:
1. Photothermal Cancer Therapy
- Mechanism: Gold nanoparticles (especially gold nanorods) absorb near-infrared light and convert it into heat, effectively destroying cancer cells through localized hyperthermia.
- Application Example: Nanopartz gold nanorods have been used in photo-thermal cancer therapy to selectively heat and destroy tumors without damaging surrounding healthy tissue.
- Research Reference: Fourkal, E., et al. "Photo-Thermal Cancer Therapy Using Gold Nanorods." World Congress on Medical Physics and Biomedical Engineering, Springer, 2009; Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.
2. Imaging and Diagnostics
- Optical Imaging: Gold nanoparticles, including gold nanorods and core-shell nanoparticles, enhance contrast in various imaging modalities such as Optical Coherence Tomography (OCT) and Surface-Enhanced Raman Scattering (SERS).
- Application Example: Nanopartz gold nanoparticles are used for imaging tumor progression and metastatic tracking. Fluorescently-labeled gold nanoparticles can be used in vivo for micro-CT and optical projection tomography.
- Research Reference: Kozomara, S. "Assessment of Fluorescently-Labeled Gold Nanoparticles in Mice as a Contrast Agent for Micro-Computed Tomography and Optical Projection Tomography." University of British Columbia, 2019.
3. Biodistribution and Cellular Uptake Studies
- Mechanism: Understanding how gold nanoparticles distribute in the body and their interaction with cancer cells helps improve therapeutic delivery and imaging efficiency.
- Application Example: Nanopartz gold nanoparticles are used in studies to track their distribution in tumors and organs, enabling optimization of dosage and targeting strategies.
- Research Reference: Janát-Amsbury, M. M., et al. "Geometry and Surface Characteristics of Gold Nanoparticles Influence Their Biodistribution and Uptake by Macrophages." European Journal of Pharmaceutics and Biopharmaceutics, 2011.
4. Photodynamic Therapy (PDT)
- Mechanism: In combination with photosensitizers, gold nanoparticles can be used in photodynamic therapy, where light activation leads to the generation of reactive oxygen species (ROS) that kill cancer cells.
- Application Example: Nanopartz gold nanoparticles, functionalized with photosensitizers, enhance the efficacy of photodynamic therapy for solid tumors.
5. Hyperthermia in Veterinary Applications
- Mechanism: Gold nanorods are used for hyperthermia treatment in veterinary oncology, where they offer minimally invasive options for treating tumors in companion animals.
- Application Example: Nanopartz gold nanorods have been successfully used for treating spontaneous neoplasia in dogs through targeted hyperthermia.
- Research Reference: Schuh, Elizabeth M., et al. "Safety and Efficacy of Targeted Hyperthermia Treatment Utilizing Gold Nanorod Therapy in Spontaneous Canine Neoplasia." BMC Veterinary Research, 2017.
Benefits of Nanopartz In Vivo Gold Nanoparticles:
- Biocompatibility: Nanopartz gold nanoparticles are biocompatible, reducing the likelihood of immune responses and ensuring safety in in vivo applications.
- Long Circulation Times:
- Enhanced Imaging: Their optical properties improve cancer diagnostics by providing clearer and more precise images in various diagnostic platforms.
- Customizable Solutions: Our gold nanoparticles are customizable for specific applications in cancer research, therapeutics, and diagnostics, ensuring they meet the exact needs of your projects.
Why Choose Nanopartz for In Vivo Gold Nanoparticles?
- Proven Performance: Our nanoparticles have been used in multiple cancer research studies and clinical trials, providing reliable performance in both therapeutic and diagnostic contexts.
- Scalable Production: Nanopartz offers scalable nanoparticle solutions, from small-scale research to large-scale clinical applications, ensuring consistency and quality at every step.
- Trusted by Researchers: Nanopartz gold nanoparticles are trusted by top researchers globally for their quality and consistent results in cancer-related applications.
Nanopartz in vivo gold nanoparticles are revolutionizing cancer therapeutics and cancer diagnostics by improving drug delivery, enhancing diagnostic imaging, and offering customizable solutions. Reach out to us today to explore how our gold nanoparticles can support your research or clinical trials.
Diameter (nm) |
Length (nm) |
Peak SPR Wave (nm) |
Aspect Ratio |
OD SPR (AU) |
Peak LSPR Wave (nm) |
OD LSPR (AU) |
Nanorods /mL |
Wt. conc (ug/ml) |
Wt. % |
PPM |
Molarity (nM) |
Picomoles |
SPR Molar Ext. (M-1cm-1) |
LSPR Molar Ext. (M-1cm-1) |
Peak SPR (nm) |
SPR Linewidth 80% (nm) |
10 |
67 |
1064 |
6.7 |
50 |
510 |
10 |
1.81E+13 |
1750 |
0.18% |
1750 |
30.13 |
3.01E+01 |
1.66E+09 |
3.32E+08 |
1022-1132 |
150 |
10 |
59 |
980 |
5.9 |
50 |
510 |
10 |
2.09E+13 |
1750 |
0.18% |
1750 |
34.91 |
3.49E+01 |
1.43E+09 |
2.86E+08 |
965-1022 |
150 |
10 |
55 |
950 |
5.5 |
50 |
510 |
10 |
2.22E+13 |
1750 |
0.18% |
1750 |
37 |
3.70E+01 |
1.35E+09 |
2.70E+08 |
925-965 |
150 |
10 |
50 |
900 |
5 |
50 |
510 |
10 |
2.47E+13 |
1750 |
0.18% |
1750 |
41.11 |
4.11E+01 |
1.22E+09 |
2.43E+08 |
875-925 |
150 |
10 |
45 |
850 |
4.5 |
50 |
510 |
10 |
2.78E+13 |
1750 |
0.18% |
1750 |
46.25 |
4.63E+01 |
1.08E+09 |
2.16E+08 |
829-875 |
100 |
10 |
41 |
808 |
4.1 |
50 |
510 |
10 |
3.10E+13 |
1750 |
0.18% |
1750 |
51.68 |
5.17E+01 |
9.68E+08 |
1.94E+08 |
794-829 |
75 |
10 |
38 |
780 |
3.8 |
50 |
510 |
10 |
3.36E+13 |
1750 |
0.18% |
1750 |
56.06 |
5.61E+01 |
8.92E+08 |
1.78E+08 |
765-794 |
65 |
Optical Density >= 50, volume = 1mL
|
All specs typical. May vary batch to batch. Exact values are measured for each batch
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Solution default is saline
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Residual Chemicals < 0.1%
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Functionalized gold nanoparticle with Nanopartz™ long circulating polymer. Thickness of polymer is 1-2nm.
Composition
These polymer coated gold nanoparticles are shipped in PBS with no measurable residual chemicals. This product is radiation sterilized and is ready for injection.
Custom Formulation
Popular CW laser wavelengths for the nanorods are available (780, 808, 850, 980, and 1064nm).
Quantity
This product is available in 1mL and larger but in two different concentrations. The lower concentration is suited for mice, while the higher concentration is suitable for companion animals. For mice, the 1mL injection is suited for 5 injections. For orders larger than 1L, or for orders amounting over 10L per annum, please contact sales for quantity pricing.
Delivery
Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays.
Conjugation
This product comes coated with a proprietary polymer to increase circulation times.
Introductory Kits
Unfortunately there are no kits available for this product at this time.
Shelf Life/Storage Temperature
This product is guaranteed for one year and may be stored at room temperature.
Toxicity
These products are non cytotoxic.
Sterilization
This product is sterilized.
Certifications
This product is manufactured using our audited ISO 9000/2001 quality control system. Every order comes with a Certification of Analysis that includes the following information. We use NIST traceable:
UV-VIS (Agilent 8453) for extinction and concentration measurements
NIR (Cary 500) for NIR extinction and concentration measurements
DLS (Malvern Nano ZS) for zeta potential measurement
ICP-MS (Varian 820-MS) for gold mass measurements
TEM (Phillips CM-100 100KV) for sizing
How much thickness does your proprietary ligand add?
Anywhere from 1-2nm.
How do I determine the concentration of the product?
Simply divide the number of nanoparticles (nps) found on the included COA by the amount of solution you add.
Why do you sell your rods as OD-mLs and what does this mean?
This is because unlike spherical gold nanoparticles, the conversion from OD to mg is not linear with nanorod diameter. Consequently, for the same OD, the weight of the nanorods increases with diameter. 50 OD-mLs means that if you resuspend the material in 1mL of solvent, you will have an absorption of OD50 through a 1mL optical path.
Can I resuspend in water?
Yes
What is the shelf life if I never open the package and keep refrigerated?
Many years.
Should I store in the refrigerator?
Yes.
How do you size your gold nanoparticles? Does the size include the capping agent?
We use three methods to specify our gold nanoparticles; TEM, UV VIS, and DLS. Each has its own advantages and disadvantages, and we use a weighted system to take advantage of each methods strengths. In the end, we place the strongest weight to the TEM method, particularly since we use samples sizes greater than 50 particles for each lot.
Do you really provide a TEM for my specific lot?
Yes, and not just for 5-10 particles, rather 50-100 are standard.
What is OD?
Optical Density (OD) is measured by UV-VIS. An Optical Density OD=1 corresponds to a transmission of 10% through a 1cm cuvette. Optical Density is a nice unit to use since Optical Densities correlate linearly to concentration. So an Optical Density of 1.2 is equal to 1.2 times the concentration of a gold nanoparticle solution that has an Optical Density of 1. We use OD and concentration interchangingly as it is easier to refer to a solution of OD=1 rather than 2.35e12 nanoparticles. For all spheres up to 200nm, OD=1 does refer to 0.05mg/mL.
What is PDI?
PDI refers to polydispersity index and is equal to the standard deviation of the particle sizes divided by the average size.
How does your polymer bridge compare to PEG?
It is superior in its resistance to salt, pH, and other chemicals.
"We have looked at many different gold nanoparticles samples from Nanopartz including spheres, rods, and microrods using single particle spectroscopy techniques and are extremely happy with the quality of the samples and the service provided by Nanopartz."
Stephan Link, PhD
Assistant Professor of Chemistry
Rice University
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Labens, R., B. D. X. Lascelles, and A. N. Charlton. "Ex Vivo Effect of Gold Nanoparticles on Porcine Synovial Membrane." Tissue Engineering and Regenerative Medicine, 2013, Taylor & Francis.
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Schoen, Christian, and Cheryl London. "Pandia® Gold Nanorods and Their Applications in Cancer Therapy and In Vivo Imaging in Companion Animals and Their Potential Application to Humans." Nanotechnology for Biomedical Imaging and Diagnostics: From Nanoparticle Design to Clinical Applications, edited by Michael Berezin, Wiley, 2014.
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Janát-Amsbury, M. M., A. Ray, and C. M. Peterson. "Geometry and Surface Characteristics of Gold Nanoparticles Influence Their Biodistribution and Uptake by Macrophages." European Journal of Pharmaceutics and Biopharmaceutics, 2011, Elsevier.
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Naha, P. C., P. Chhour, and D. P. Cormode. "Systematic in Vitro Toxicological Screening of Gold Nanoparticles Designed for Nanomedicine Applications." Toxicology in Vitro, 2015, Elsevier.
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Kozomara, S. "Assessment of Fluorescently-Labeled Gold Nanoparticles in Mice as a Contrast Agent for Micro-Computed Tomography and Optical Projection Tomography." University of British Columbia, 2019. open.library.ubc.ca.
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Kozomara, S., and N. L. Ford. "Imaging of Murine Melanoma Tumors Using Fluorescent Gold Nanoparticles." Medical Imaging 2019: Biomedical Applications in Molecular, Structural, and Functional Imaging, SPIE, 2019.
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Kozomara, S., and N. L. Ford. "Detectability of Fluorescent Gold Nanoparticles Under Micro-CT and Optical Projection Tomography Imaging." Journal of Medical Imaging, 2020, spiedigitallibrary.org.
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Galanzha, E. I., E. Shashkov, M. Sarimollaoglu, and V. P. Zharov. "In Vivo Magnetic Enrichment, Photoacoustic Diagnosis, and Photothermal Purging of Infected Blood Using Multifunctional Gold and Magnetic Nanoparticles." PLOS ONE, 2012.
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Boyoglu, C., Q. He, and G. Willing. "Microscopic Studies of Various Sizes of Gold Nanoparticles and Their Cellular Localizations." International Journal of Nanomedicine, 2013, Wiley Online Library.
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Li, W. B., S. Stangl, A. Klapproth, M. Shevtsov, and T. Multhoff. "Application of High-Z Gold Nanoparticles in Targeted Cancer Radiotherapy—Pharmacokinetic Modeling, Monte Carlo Simulation and Radiobiological Effect." Cancers, 2021, MDPI.
The manufacturing method for these nanoparticles are based on our proprietary method. This family of products have resulted in hundreds ofpublications and is the cornerstone of our product line.
| Nanopartz™ in vivo Gold Nanoparticles | Other Polymers like PEG Gold Nanoparticles | |
| Stability (salt,pH,chemicals) | High | Medium |
| Monovalent | Yes | No |
| Nonspecific binding | Very low | Medium |
| Sterilization | Yes | No |
| Circulation Time | Long | Low |
| Toxicity | None | Broad |
| Photothermal efficiency | Highest recorded | Low |
| Imaging potential | Yes | Very Limited |
| Drug Delivery potential | Yes | Very Limited |
| Tumor Loading | High | Low |
- Covalent bonds insure specificity, stability, long shelf life
- Buffer Stability - stable from pH 4-9
- No sodium azide
- No BSA
- Polymer coating insures no aggregation in high salts, reduced nonspecific binding
- Stable
- Well Characterized
- Customer can select buffer
- Customer can select gold nanoparticle type, size and/or SPR
- Loading of all ligands is optimized
Example part number is D12-10-808-VM-DIH-50-1-CS-EP where:
D12 - Product family number for in vivo gold nanorods
10-808 - Diameter and SPR of nanorod
VM - in vivo long circulating methyl polymer
DIH - Buffer, in this case 18MEG DI water. Other choices are PBS, MES, Sodium Borate, TRIS
50 - Optical Density, in this case OD=50, optional 250
1 - Volume (mL). Other choices are 5mL, 10mL and more.
CS - Certified Sterilized - Though the product come sterilized, this option includes testing and certification.
EP - Endotoxin Purified - The product is endotoxin purified and certified.
Ordering by scrolling down and selecting the options from the selection below.