Nanopartz Magnetic and Gold Coated Magnetic Nanoparticles

Composition

These spherical magnetic nanoparticles are shipped in  DI water with no measurable residual reactants. These particles are not manufactured in citrate. Citrate and the other ligands are functionalized after manufacturing allowing for a minimal, controlled amount of ligand to be used.

Custom Formulation

Diameters 2 to 250nm.  Other sizes are special order.  Please contact us

Quantity

This product is available in 1mL volumes and larger. For the oligo products, the oligo is limited to 70nmoles. For the smaller sizes of nanoparticles, depending on whether the monovalent option is purchased, the amount of nanoparticles will be limited by the upper limit of the oligo. For example, for the 2nm product, if the monovalent option is purchased, you will received 70nmoles of nanoparticles.

Delivery

Standard sizes are in stock. Special order sizes are shipped in two weeks or less. All domestic shipments are sent Fed Ex Standard Overnight delivery, international Fed Ex Priority 2 day. No shipments on Fridays except for dried particles. Saturday shipping available for extra charge.

Functionalization

This product comes with different adsorbed ligands: our proprietary carboxylic acid, citrate, and with PEI, PAH, PAA, BSA, and PVP polymers.

Shelf Life/Storage Temperature

This product is guaranteed for six months and should be stored at 4 °C after opening. Care must be taken to only use sterile glassware when working with this product.

Toxicity

This product is known to be noncytotoxic unless shipped in CTAB. This product has been sterilized and is biological free.

Sterilization

This product is sterilized.

Certifications

Every order comes with a Certification of Analysis that includes the following information. We use calibration traceable:

UV-VIS (Agilent 8453) for extinction and concentration measurements

NIR (Cary 500) for NIR extinction and concentration measurements

DLS (Malvern Nano ZS) for zeta potential measurement

ICP-MS (Varian 820-MS) for mass measurements

TEM (Phillips CM-100 100KV) for sizing

TN602 Storage and Handling

SDS Part # A11

How do you size your magnetic nanoparticles? Does the size include the capping agent?

We use two methods to size our magnetic nanoparticles; TEM, and DLS. Each has its own advantages and disadvantages, and we use a weighted system to take advantage of each methods strengths. In the end, we place the strongest weight to the TEM method, particularly since we use samples sizes greater than 50 particles for each lot.

Do you really provide a TEM for my specific lot?

Yes, and not just for 5-10 particles, rather 50-100 are standard.

What is OD?

Optical Density (OD) is measured by UV-VIS. An Optical Density OD=1 corresponds to a transmission of 10% through a 1cm cuvette. Optical Density is a nice unit to use since Optical Densities correlate linearly to concentration. So an Optical Density of 1.2 is equal to 1.2 times the concentration of a gold nanoparticle solution that has an Optical Density of 1. We use OD and concentration interchangingly as it is easier to refer to a solution of OD=1 rather than 2.35e12 nanoparticles. For all spheres up to 200nm, OD=1 does refer to 0.05mg/mL.

What is PDI?

PDI refers to polydispersity index and is equal to the standard deviation of the particle sizes divided by the average size.

"We were previously making our own gold nanoparticles using the commonly used technique of citrate reduction of Au(III). The colloids generated are broadly polydisperse, and we were concerned that our application of these particles in immuno-gold labeling of cells for optical coherence microscopy (OCM) would be utilizing only the large diameter tail of the distribution. We purchased the sampler package of NanoPartz gold spheres (30 nm, 50 nm, 70 nm, 90 nm) and examined each size carefully with dynamic light scattering, OCM, and spectrophotometry. Our measurements indicated diameters a couple nanometers larger than specifications (a result of measurements on the fully hydrated state?), and remarkable monodispersity - within specs. It is clear to us now that our early immuno-gold results were dominated by the largest diameter spheres of our early colloids. We are delighted by the NanoPartz monodisperse preparations and recommend them strongly!"

Dr. Richard C. Haskell 
Professor of Physics & Director of Physics Clinic 
Physics Department 
Harvey Mudd College

"The scientists at Nanopartz have developed a line of colloidal gold nanorods with extremely high monodispersity in size, shape, and mass. The surfactant layer is highly stable and readily displaced for biofunctionalization. In every test, in vitro and in vivo, these materials have exceeded our expectations."

Geoffrey A. von Maltzahn
NSF and Whitaker Graduate Fellow
Harvard-MIT Division of Health Sciences and Technology
Laboratory for Multiscale Regenerative Technologies

The manufacturing method for these nanoparticles are based on our proprietary method. This invention allows the first use of a reducing agent to be used at room temperature. Unlike citrate which is only a reducing agent at the boiling temperature of water - thereby quickly making non-monodisperse magnetic nanoparticles, our reducing agent works by slowing building nanoparticles from seed, atom by atom, over the course of up to hours. The result is a highly monodisperse product with unrivaled spherical shapes.

• Highly accurate and monodisperse in size, shape, and batch to batch uniformity.
  • Monodisperse sizes and shapes leads to better standards for electron microscopy and other diagnostics.
• Accurate to +/- 5 nm in diameter.
  • More accurate sizing makes for better SPR matching for Surface Enhanced Raman Labels.
• Size monodispersity better than 10% CV for many sizes.
• Facile conjugations allow for coating of antibodies, receptors, ligands, and DNA.
• Slightly negatively charged (reduced aggregation).
• Facile synthesis.